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Yoshimi Takai Selected Research

poliovirus receptor

3/2018Roles of the third Ig-like domain of Necl-5/PVR and the fifth Ig-like domain of the PDGF receptor in its signaling.
6/2007Necl-5/poliovirus receptor interacts in cis with integrin alphaVbeta3 and regulates its clustering and focal complex formation.
3/2007Regulation of platelet-derived growth factor-induced Ras signaling by poliovirus receptor Necl-5 and negative growth regulator Sprouty2.
1/2007Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells.
10/2005Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.
3/2005Transcriptional activation of the mouse Necl-5/Tage4/PVR/CD155 gene by fibroblast growth factor or oncogenic Ras through the Raf-MEK-ERK-AP-1 pathway.
8/2004Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling.

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Yoshimi Takai Research Topics

Disease

23Neoplasms (Cancer)
06/2022 - 12/2002
3Breast Neoplasms (Breast Cancer)
06/2022 - 12/2019
3Alzheimer Disease (Alzheimer's Disease)
11/2012 - 05/2009
3Infertility (Sterility)
09/2006 - 07/2002
3Carcinoma (Carcinomatosis)
03/2005 - 07/2003
2Neoplasm Metastasis (Metastasis)
01/2021 - 12/2019
2Fibrosis (Cirrhosis)
07/2013 - 10/2009
2Kidney Diseases (Kidney Disease)
08/2011 - 12/2008
2Wounds and Injuries (Trauma)
01/2010 - 10/2009
2Herpes Zoster
06/2008 - 10/2003
2Warburg Sjo Fledelius syndrome
01/2008 - 03/2005
1Mental Disorders (Mental Disorder)
01/2022
1Inborn Genetic Diseases (Disease, Hereditary)
01/2016
1Double cortex
09/2015
1Tropical Spastic Paraparesis (Tropical Spastic Paraplegia)
03/2015
1T-Cell Leukemia (Leukemia, T Cell)
03/2015
1Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
03/2015
1Inflammation (Inflammations)
11/2014
1Cardiovascular Diseases (Cardiovascular Disease)
10/2014
1Schizophrenia (Dementia Praecox)
12/2013
1Lung Neoplasms (Lung Cancer)
04/2013
1Colonic Neoplasms (Colon Cancer)
03/2013
1Hypoxia (Hypoxemia)
03/2013
1Hydrocephalus (Hydrocephaly)
01/2013
1Pathologic Constriction (Stenosis)
01/2013
1Ischemia
03/2012
1Genetic Translocation (Chromosomal Translocation)
02/2012
1Adenocarcinoma
10/2011
1Hypertension (High Blood Pressure)
08/2011
1Ectodermal Dysplasia (Aplasia Cutis Congenita)
10/2010
1Glomerulonephritis
01/2010
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2009
1Virus Diseases (Viral Diseases)
10/2009
1Memory Disorders (Memory Loss)
05/2009
1Cysts
03/2009
1Chronic Renal Insufficiency
12/2008
1Albuminuria
12/2008
1Starvation
06/2008
1Intellectual Disability (Idiocy)
01/2008
1Martsolf syndrome
01/2008
1Infections
07/2007
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
07/2007

Drug/Important Bio-Agent (IBA)

24NectinsIBA
01/2022 - 06/2002
7poliovirus receptorIBA
03/2018 - 08/2004
6Proteins (Proteins, Gene)FDA Link
01/2021 - 05/2004
6Cell Adhesion MoleculesIBA
12/2019 - 01/2007
6Immunoglobulins (Immunoglobulin)IBA
03/2018 - 10/2005
4afadinIBA
09/2015 - 06/2008
3DNA (Deoxyribonucleic Acid)IBA
06/2022 - 12/2019
3LigandsIBA
01/2015 - 08/2009
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
11/2012 - 05/2009
3Cadherins (E-Cadherin)IBA
10/2009 - 06/2002
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2007 - 10/2005
2Trastuzumab (Herceptin)FDA Link
06/2022 - 01/2021
2Oncogene Proteins (Oncogene Protein)IBA
03/2015 - 05/2004
2Messenger RNA (mRNA)IBA
04/2013 - 03/2013
2matrigelIBA
03/2012 - 03/2009
2Laminin (Merosin)IBA
10/2011 - 09/2010
2IntegrinsIBA
10/2011 - 09/2010
2Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
08/2011 - 12/2008
2AldosteroneIBA
08/2011 - 12/2008
2GTP Phosphohydrolases (GTPases)IBA
08/2011 - 12/2008
2Tyrosine (L-Tyrosine)FDA Link
08/2009 - 03/2007
2Integrin alphaVbeta3IBA
08/2008 - 06/2007
2Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
08/2008 - 03/2007
2GTPase-Activating Proteins (GTPase-Activating Protein)IBA
01/2008 - 03/2005
1SuspensionsIBA
06/2022
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2022
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
12/2019
1Phosphatidylinositols (Phosphatidylinositol)IBA
12/2019
1Chemokine ReceptorsIBA
01/2015
1CytokinesIBA
11/2014
1Soluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsIBA
10/2014
1Biological ProductsIBA
12/2013
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
07/2013
1Angiotensin IIIBA
07/2013
1Cell Adhesion Molecule-1IBA
04/2013
13' Untranslated Regions (3' UTR)IBA
03/2013
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2012
1Transcription Factors (Transcription Factor)IBA
08/2011
1SaltsIBA
08/2011
1SteroidsIBA
08/2011
1Monomeric GTP-Binding ProteinsIBA
08/2011
1Extracellular Matrix ProteinsIBA
09/2010
1Integrin alpha6beta4IBA
09/2010
1Glycoproteins (Glycoprotein)IBA
01/2010
1Peptides (Polypeptides)IBA
11/2009
1Amyloid beta-PeptidesIBA
11/2009
1class-I restricted T cell-associated moleculeIBA
10/2009
1Guanine Nucleotide Dissociation Inhibitors (GDIs)IBA
12/2008
1Carrier Proteins (Binding Protein)IBA
06/2008
1CateninsIBA
06/2008
1ClaudinsIBA
06/2008
1Fas Ligand Protein (Fas Ligand)IBA
06/2008
1Member 14 Tumor Necrosis Factor ReceptorsIBA
07/2007
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2007
1Platelet-Derived Growth FactorIBA
03/2007
1rho Guanine Nucleotide Dissociation Inhibitor alphaIBA
01/2007

Therapy/Procedure

1Heterologous Transplantation (Xenotransplantation)
01/2015
1Therapeutics
07/2007